To explore the expression of
leukemia-related
protein 16 (LRP16) in invasive ductal
breast carcinoma and analyze its correlation with clinicopathological feature and prognosis, immunohistochemistry was performed on 100 cases of invasive ductal
breast carcinoma. Medical records were reviewed and clinicopathological analysis was performed.
Leukemia-related
protein 16 expression was detected in 33 of 100 cases (33%) of the invasive ductal
breast carcinoma. Expression of LRP16 in
carcinoma was obviously higher than that in normal breast tissue. LRP16
protein expression was found in 27.6% (21/76) of
carcinoma at stage I and II, and 50.0% (12/24) of
carcinoma at stage III and IV. LRP16 expression was found correlative with
metastasis in the axillary lymph node (P = 0.001), stage (P = 0.042),
estrogen receptor (ER) expression (P = 0.001), fragile
histidine triad (FHIT) expression (P = 0.015) and CD133 expression (P = 0.038), but not with grade (P = 0.543),
tumor size (P = 0.263), age (P = 0.840), menopause (P = 0.701) and HER-2 gene amplification (P = 0.463). The difference of the mean disease free survival (DFS) time between
cancer patients with LRP16 expression (43.7 months) and those without (77.7 months) was statistically significant (Log rank = 9.989, P = 0.002). The difference of the mean overall survival (OS) time between
cancer patients with LRP16 expression (50.0 months) and those without (120.0 months) was statistically significant (Log rank = 9.977, P = 0.002). Our finding suggests that expression of LRP16
protein is correlated with the stage,
metastasis, prognosis and expression of ER,
progesterone receptor, Ki-67, CD133 and FHIT in invasive ductal
breast carcinoma.