A chromosomal translocation causing overproduction of iso-2-cytochrome c in yeast.

Abstract

The CYC7-1 mutation in the yeast Saccharomyces cerevisiae causes the production of approximately 30 times the normal amount of iso-2-cytochrome c. Genetic analysis established that the CYC7-1 mutation is a reciprocal translocation involving the left arm of chromosome V and the right arm of chromosome XVI. The chromosome V arm was broken adjacent to the gene CYC7, which determines the primary structure of iso-2-cytochrome c, and this fragment containing the CYC7 gene was joined to the segment of chromosome XVI. It appears as though the elevation of iso-2-cytochrome c is caused by an abnormal controlling region adjacent to the structural region of the CYC7 gene.

• Authors: F Sherman, C Helms
• Journal: Genetics (Genetics) Vol. 88 Issue 4 Pt 1 Pg. 689-707 (Apr 1978) ISSN: 0016-6731 [Print] United States
• PMID: 206486 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cytochrome c Group

Topics

• Cytochrome c Group (biosynthesis, genetics)
• Genes
• Genes, Regulator
• Genetic Linkage
• Mutation
• Saccharomyces cerevisiae
• Translocation, Genetic