Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus.

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. In this paper we evaluate anti-nucleoporin p62 antibodies by western blot analysis in 25 systemic lupus erythematosus patients. Six patients showed antibodies directed against nucleoporin p62. Our data indicate that p62 antibodies could be a useful additional marker in SLE.

• Authors: Doris M Kraemer, Hans-Peter Tony
• Journal: The open rheumatology journal (Open Rheumatol J) Vol. 4 Pg. 24-7 (May 13 2010) ISSN: 1874-3129 [Electronic] United Arab Emirates
• PMID: 20648220 (Publication Type: Journal Article)