[S-1-based chemotherapy for recurrent gastric cancer with peritoneal dissemination resulting in long-term survival--report of a case].
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| Abstract |
A 52-year-old man underwent distal gastrectomy for gastric cancer in July 2000. In July 2005, abdominal CT and barium study of the colon revealed peritoneal recurrence, and chemotherapy of S-1 was started. Within 2 courses, the serum CEA level increased, so combination chemotherapy of S-1 and cisplatin (CDDP) was begun. After 7 courses, the regimen was switched to S-1+paclitaxel (PTX). However, the patient developed digital numbness within 8 courses and single-agent chemotherapy with S-1 was restarted. In July 2007, he developed abdominal distension, and abdominal CT showed a large amount of ascites. S-1+CDDP was administered again, however, and we had to change the regimen within 3 courses due to fatigue and appetite loss. S-1 was restarted, but soon severe fatigue and appetite loss restricted the use of chemotherapeutic agents, and he died in December. This patient had been alive for 2 years and 5 months since peritoneal recurrence was diagnosed. We concluded that S-1-based sequential chemotherapy was effective for recurrent gastric cancer.
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| Authors | Tomoyuki Wakahara, Akihiro Toyokawa, Ayako Tomono, Soichiro Tani, Taku Yamamichi, Narutomo Nishioka, Hidetoshi Gon, Hironori Yamashita, Takayoshi Nakajima, Kiyonori Kanemitsu, Tsuyoshi Takahashi, Toyokazu Okuda, Ken-ichi Tanaka, Tadashi Tsukamoto, Yutaka Hamabe, Takeshi Iwasaki, Takeshi Ishida |
| Journal | Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 37 Issue 7 Pg. 1361-4 (Jul 2010) ISSN: 0385-0684 [Print] Japan |
| PMID | 20647727 (Publication Type: Case Reports, Journal Article) |
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