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[Selection of anticancer drug for poorly-differentiated adenocarcinoma of colorectum from the level of orotate phosphoribosyl transferase and dihydropyrimidine dehydrogenase activities in cancer tissue].

Abstract
We investigated the relationship between DPD, OPRT activities and clinicopathological characteristics in 76 patients with colorectal cancer. There was no significant difference between cancer and normal tissue in DPD activity. OPRT activity was significantly higher in cancer tissue than in normal tissue. In poorly-differentiated adenocarcinoma, DPD activity was significantly higher, and OPRT activity was significantly lower than the other type of cancer. Furthermore, OPRT activity was significantly lower in patients with lymph node metastasis. These results suggested that poorly-differentiated adenocarcinoma of the colorectum shows lower efficacy with treatment by 5-fluorouracil than other types of colorectal cancer. Hence, DPD inhibitory fluorouracil, such as S-1, may have potent therapeutic efficacy for poorly-differentiated adenocarcinoma of the colorectum.
AuthorsMasashi Takemura, Keiichirou Morimura, Kayo Yoshida, Harushi Osugi, Shigeru Lee, Satoru Kishida
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 37 Issue 7 Pg. 1297-301 (Jul 2010) ISSN: 0385-0684 [Print] Japan
PMID20647713 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Dihydrouracil Dehydrogenase (NADP)
  • Orotate Phosphoribosyltransferase
  • Fluorouracil
Topics
  • Adenocarcinoma (drug therapy, enzymology, pathology)
  • Aged
  • Antineoplastic Agents (therapeutic use)
  • Cell Differentiation
  • Colorectal Neoplasms (drug therapy, enzymology, pathology)
  • Dihydrouracil Dehydrogenase (NADP) (metabolism)
  • Female
  • Fluorouracil (therapeutic use)
  • Humans
  • Male
  • Orotate Phosphoribosyltransferase (metabolism)

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