Abstract | OBJECTIVE: DESIGN: Case series of 3 consecutive patients who had extensive, symptomatic airway infantile hemangiomas treated with propranolol. SETTING: Tertiary academic medical center. PATIENTS: Three infants with facial cutaneous hemangiomas who developed stridor that progressed to respiratory distress, which according to laryngoscopic examination results was confirmed to be caused by extensive subglottic hemangiomas. These patients underwent follow-up during their course of therapy, ranging from 3 weeks to 15 months. RESULTS: CONCLUSIONS: Our 3 patients had severe respiratory symptoms related to their airway infantile hemangiomas. In the first patient, propranolol was used when other treatments were ineffective or associated with intolerable adverse effects. In the second and third patients, propranolol was part of a dual regimen that resulted in rapid resolution of airway symptoms and allowed for quicker weaning of corticosteroids.
|
Authors | Kristina W Rosbe, Ki-Young Suh, Anna K Meyer, Sheilagh M Maguiness, Ilona J Frieden |
Journal | Archives of otolaryngology--head & neck surgery
(Arch Otolaryngol Head Neck Surg)
Vol. 136
Issue 7
Pg. 658-65
(Jul 2010)
ISSN: 1538-361X [Electronic] United States |
PMID | 20644059
(Publication Type: Journal Article)
|
Chemical References |
- Adrenal Cortex Hormones
- Propranolol
|
Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Airway Obstruction
(congenital, therapy)
- Combined Modality Therapy
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Glottis
(pathology)
- Hemangioma
(congenital, diagnosis, drug therapy, surgery)
- Humans
- Infant
- Infant, Newborn
- Laryngeal Neoplasms
(congenital, diagnosis, drug therapy, surgery)
- Laryngoscopy
- Male
- Propranolol
(therapeutic use)
- Risk Assessment
- Sampling Studies
- Skin Neoplasms
(congenital, diagnosis, therapy)
- Tracheostomy
(methods)
- Treatment Outcome
|