High frequency of hand foot syndrome with capecitabine.

Abstract

A hospital based cross-sectional retrospective study was conducted to determine the frequency of hand foot syndrome (HFS) with Capecitabine as a single agent and in combination with Oxaliplatin. The study included 43 consecutive cases of colorectal carcinoma and conducted from June till December 2008. Patients on palliative care were excluded. SPSS was used for the application of chi-square test, by keeping the level of significance as p < 0.05. Fifteen (34.9%) patients developed HFS, 10 in the single-agent and 5 in the combination group. No significant association of HFS with either regimens was noted (p=0.876).

• Authors: Muhammad Kamil, Mubassir Haron, Narazah Yosuff, Imran Khalid, Nizuwan Azman
• Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP (J Coll Physicians Surg Pak) Vol. 20 Issue 6 Pg. 421-2 (Jun 2010) ISSN: 1022-386X [Print] Pakistan
• PMID: 20642979 (Publication Type: Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Organoplatinum Compounds
• Oxaliplatin
• Deoxycytidine
• Capecitabine
• Fluorouracil

Topics

• Adult
• Aged
• Antimetabolites, Antineoplastic (administration & dosage, adverse effects)
• Capecitabine
• Colorectal Neoplasms (drug therapy)
• Cross-Sectional Studies
• Deoxycytidine (administration & dosage, adverse effects, analogs & derivatives)
• Drug Therapy, Combination
• Female
• Fluorouracil (administration & dosage, adverse effects, analogs & derivatives)
• Foot Dermatoses (chemically induced)
• Hand Dermatoses (chemically induced)
• Humans
• Male
• Middle Aged
• Organoplatinum Compounds (administration & dosage, adverse effects)
• Oxaliplatin
• Syndrome