Comparison of antimalarial efficacy of alpha, beta, and alpha/beta arteether against Plasmodium cynomolgi B infection in monkeys.

Abstract

The blood schizontocidal activity of alpha and beta arteether has been compared with that of alpha/beta arteether (a 30:70 mixture of alpha and beta isomers), which is a fast-acting blood schizontocide undergoing phase I clinical trials at the Central Drug Research Institute. Both beta and alpha/beta arteether have comparable activity and are curative at a dose of 5 mg/kg for 3 days against blood-induced Plasmodium cynomolgi B infection in the rhesus monkey; alpha arteether alone is slightly less active, with a 50% cure rate at the above dose.

• Authors: R Tripathi, G P Dutta, R A Vishwakarma
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 44 Issue 5 Pg. 560-3 (May 1991) ISSN: 0002-9637 [Print] United States
• PMID: 2063959 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antimalarials
• Artemisinins
• Sesquiterpenes
• artemotil

Topics

• Animals
• Antimalarials (therapeutic use)
• Artemisinins
• Female
• Malaria (drug therapy)
• Male
• Sesquiterpenes (therapeutic use)