Rituximab in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a report of 13 cases and review of the literature.

Abstract

BACKGROUND:

A few case reports have shown controversial results of rituximab efficacy in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).

OBJECTIVE:

To analyse the efficacy of rituximab in a large CIDP cohort.

METHODS:

A retrospective, observational and multicentre study on the use of rituximab in CIDP. 13 Italian CIDP patients were treated with rituximab after the partial or complete lack of efficacy of conventional therapies. Eight patients had co-occurring haematological diseases. Patients who improved by at least two points in standard clinical scales, or who reduced or discontinued the pre-rituximab therapies, were considered as responders.

RESULTS:

Nine patients (seven with haematological diseases) responded to rituximab: six of them, who were non-responders to conventional therapies, improved clinically, and the other three maintained the improvement that they usually achieved with intravenous immunoglobulin or plasma exchange. Significantly associated with shorter disease duration, rituximab responses started after a median period of 2.0 months (range, 1-6) and lasted for a median period of 1 year (range, 1-5).

CONCLUSIONS:

Rituximab seems to be a promising therapeutic choice when it targets both CIDP and co-occurring haematological diseases. Timely post-onset administration of rituximab seems to be associated with better responses.

• Authors: L Benedetti, C Briani, D Franciotta, R Fazio, I Paolasso, C Comi, M Luigetti, M Sabatelli, F Giannini, G L Mancardi, A Schenone, E Nobile-Orazio, D Cocito
• Journal: Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 82 Issue 3 Pg. 306-8 (Mar 2011) ISSN: 1468-330X [Electronic] England
• PMID: 20639381 (Publication Type: Case Reports, Journal Article, Multicenter Study, Review)

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Immunologic Factors
• Rituximab

Topics

• Adult
• Aged
• Antibodies, Monoclonal, Murine-Derived (therapeutic use)
• Child
• Female
• Humans
• Immunologic Factors (therapeutic use)
• Male
• Middle Aged
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (drug therapy, immunology, physiopathology)
• Retrospective Studies
• Rituximab
• Treatment Outcome