Abstract | PURPOSE: MATERIALS AND METHODS: We used 80 male Sprague-Dawley rats to test various doses of intrathecal 5-hydroxymethyl tolterodine and/or intrathecal doxazosin on urodynamic parameters. Urodynamic evaluation without anesthesia was done 3 days after bladder and intrathecal catheterization. Two weeks before urodynamics 40 rats underwent partial urethral obstruction. RESULTS: Intrathecal 5-hydroxymethyl tolterodine had no urodynamic effects in nonobstructed rats. Compared to controls obstructed rats had increased bladder pressure and weight, and voiding frequency. In obstructed rats 5-hydroxymethyl tolterodine restored urodynamic parameters to those seen in nonobstructed animals. Doxazosin had effects similar to those of intrathecal 5-hydroxymethyl tolterodine. When the 2 drugs were combined, at the doses used only small additional effects were observed. CONCLUSIONS:
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Authors | Claudius Füllhase, Roberto Soler, Christian Gratzke, Marina Brodsky, George J Christ, Karl-Erik Andersson |
Journal | The Journal of urology
(J Urol)
Vol. 184
Issue 2
Pg. 783-9
(Aug 2010)
ISSN: 1527-3792 [Electronic] United States |
PMID | 20639056
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- 5-hydroxymethyl tolterodine
- Adrenergic alpha-Antagonists
- Benzhydryl Compounds
- Cresols
- fesoterodine
- Doxazosin
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Topics |
- Adrenergic alpha-Antagonists
(pharmacology, therapeutic use)
- Animals
- Benzhydryl Compounds
(metabolism, pharmacology, therapeutic use)
- Cresols
(metabolism, pharmacology, therapeutic use)
- Doxazosin
(pharmacology, therapeutic use)
- Drug Therapy, Combination
- Male
- Rats
- Rats, Sprague-Dawley
- Spinal Cord
(drug effects)
- Urethral Obstruction
(drug therapy)
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