Abstract | PURPOSE: MATERIALS AND METHODS: We used normal female rats and rats with stress urinary incontinence induced by vaginal distention. Urethral responses were measured using a microtransducer tipped catheter. We evaluated the effect of low dose duloxetine (0.1 mg/kg), alpha(2)-adrenoceptor antagonists ( idazoxan or yohimbine) and sequential administration of drugs on urethral pressure response amplitude during sneezing and urethral baseline pressure. Sneeze induced leak point pressure was also measured. RESULTS: In normal and vaginally distended rats low dose duloxetine did not alter urethral pressure response amplitude during sneezing but it significantly increased urethral baseline pressure. When low dose duloxetine was co-applied with alpha(2)-adrenoceptor antagonists, urethral pressure response amplitude during sneezing was significantly increased. In all 7 vaginally distended rats leakage was observed during sneezing. After low dose duloxetine administration fluid leakage still occurred during sneezing. However, after low dose duloxetine and idazoxan co-administration fluid leakage disappeared in 2 of 7 rats and sneeze induced leak point pressure was significantly increased in the remaining incontinent rats with vaginal distention. CONCLUSIONS:
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Authors | Takeya Kitta, Minoru Miyazato, Michael B Chancellor, William C de Groat, Katsuya Nonomura, Naoki Yoshimura |
Journal | The Journal of urology
(J Urol)
Vol. 184
Issue 2
Pg. 762-8
(Aug 2010)
ISSN: 1527-3792 [Electronic] United States |
PMID | 20639053
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Adrenergic alpha-2 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Serotonin Uptake Inhibitors
- Thiophenes
- Yohimbine
- Duloxetine Hydrochloride
- Idazoxan
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Topics |
- Adrenergic alpha-2 Receptor Antagonists
- Adrenergic alpha-Antagonists
(pharmacology)
- Animals
- Drug Synergism
- Duloxetine Hydrochloride
- Female
- Idazoxan
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Reflex
(drug effects)
- Selective Serotonin Reuptake Inhibitors
(pharmacology)
- Sneezing
(physiology)
- Thiophenes
(pharmacology)
- Urethra
(physiopathology)
- Urinary Incontinence, Stress
(physiopathology)
- Yohimbine
(pharmacology)
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