Vaccination with a chaperone complex based on PSCA and GRP170 adjuvant enhances the CTL response and inhibits the tumor growth in mice.

Abstract	Increasing knowledge demonstrate that prostate stem cell antigen (PSCA) is a promising candidate for immunotherapy of advanced prostate cancer. However, tumor escape with down-regulation of target antigens may limit the susceptibility of tumor cells to the immune attack. Concomitant generation of T-cell responses against several immunodominant antigens may circumvent this potential drawback. In this study, we prepared the chaperone complex vaccine based on PSCA and GRP170, and utilized it to immunize the C57BL/6 mice. In addition, the T-cell response was monitored with ELISPOT and (51)Cr-release assays, and the tumor growth and the life span of tumor-bearing mice were assessed. The results demonstrated the chaperone complex based on PSCA and GRP170 could enhance the T-cell mediate immune responses, which significantly inhibited the tumor growth and prolonged the life span of tumor-bearing mice. In conclusion, our findings supported the strategy of chaperone complex, based on PSCA and GRP170, could be an effective treatment for prostate cancer therapy.
Authors	Wenqian Huo, Jin Ye, Rongrong Liu, Jin Chen, Qiansheng Li
Journal	Vaccine (Vaccine) Vol. 28 Issue 38 Pg. 6333-7 (Aug 31 2010) ISSN: 1873-2518 [Electronic] Netherlands
PMID	20637304 (Publication Type: Journal Article)
Copyright	(c) 2010. Published by Elsevier Ltd.
Chemical References	Antigens, Neoplasm Cancer Vaccines GPI-Linked Proteins Glycoproteins HSP70 Heat-Shock Proteins Immunodominant Epitopes Membrane Glycoproteins Molecular Chaperones Neoplasm Proteins Psca protein, mouse glucose-regulated protein 170
Topics	Animals Antigens, Neoplasm (immunology) Cancer Vaccines (immunology) Cell Line, Tumor GPI-Linked Proteins Glycoproteins (immunology) HSP70 Heat-Shock Proteins (immunology) Immunodominant Epitopes (immunology) Male Membrane Glycoproteins (immunology) Mice Mice, Inbred C57BL Molecular Chaperones (immunology) Neoplasm Proteins (immunology) T-Lymphocytes, Cytotoxic (immunology)

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