Abstract | OBJECTIVES: METHODS: KEY FINDINGS: YPF-P dose-dependently alleviated the degree of liver fibrosis and inhibited hepatic stellate cell transformation into myofibroblast-like cells, markedly reduced the elevated levels of hyaluronic acid, laminin, type IV collagen, type III procollagen, hydroxyproline and transforming growth factor beta-1, suppressed procollagen I, collagen III and TIMP-1 expression, and improved the TIMP-1/ MMP-13 ratio. MMP-13 expression was only promoted moderately by YPF-P. Compared with AP, YPF-P showed more potency on most markers except laminin, type IV collagen and MMP-13 mRNA. CONCLUSIONS: YPF-P prevented the progress of rat liver fibrosis induced by carbon tetrachloride and had a more potent preventative effect. The preventative effect may be associated with the ability of YPF-P to inhibit the synthesis of matrix collagen and balance the TIMP/ MMP system.
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Authors | Jia-Jia Wang, Jun Li, Lei Shi, Xiong-Wen Lv, Wen-Ming Cheng, Ying-Ying Chen |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 62
Issue 7
Pg. 935-42
(Jul 2010)
ISSN: 2042-7158 [Electronic] England |
PMID | 20636883
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- Fibrillar Collagens
- Laminin
- Polysaccharides
- Protective Agents
- RNA, Messenger
- Transforming Growth Factor beta1
- yu ping feng san
- Hyaluronic Acid
- Matrix Metalloproteinases
- Hydroxyproline
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Topics |
- Animals
- Apiaceae
- Astragalus propinquus
- Atractylodes
- Carbon Tetrachloride Poisoning
(drug therapy, metabolism, pathology)
- Chemical and Drug Induced Liver Injury
(metabolism, pathology, prevention & control)
- Dose-Response Relationship, Drug
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Fibrillar Collagens
(genetics, metabolism)
- Hepatic Stellate Cells
(drug effects, metabolism, pathology)
- Hyaluronic Acid
(metabolism)
- Hydroxyproline
(metabolism)
- Laminin
(metabolism)
- Liver Cirrhosis, Experimental
(metabolism, pathology, prevention & control)
- Magnoliopsida
- Male
- Matrix Metalloproteinases
(genetics, metabolism)
- Phytotherapy
- Plant Roots
- Polysaccharides
(pharmacology, therapeutic use)
- Protective Agents
(pharmacology, therapeutic use)
- RNA, Messenger
(metabolism)
- Rats
- Rhizome
- Transforming Growth Factor beta1
(metabolism)
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