Transcatheter arterial chemoembolization with a fine-powder formulation of cisplatin for hepatocellular carcinoma.

Abstract

AIM:

To evaluate the efficacy of transcatheter arterial chemoembolization (TACE) using a suspension of a fine-powder formulation of cisplatin (DDPH) for hepatocellular carcinoma (HCC).

METHODS:

The study population was comprised of 164 patients who were treated by TACE alone. Of these patients, 76 underwent TACE using a suspension of DDPH in lipiodol (LPD) (DDPH group), and the remaining 88 underwent TACE with an emulsion of doxorubicin (ADM) with LPD (ADM group). We compared the DDPH group with the ADM group in terms of the objective early response rate, progression free survival (PFS) and overall survival (OS).

RESULTS:

The objective early response rate in the DDPH group was significantly higher than that in the ADM group (54% vs 24%, P < 0.001). The PFS rate in the DDPH group was also significantly higher than that in the ADM group (P < 0.001). Moreover, the OS in the DDPH group was significantly longer than that in the ADM group (P = 0.002). Although the incidence rate of nausea or vomiting in the DDPH group was higher than that in the ADM group, the ADM group showed a higher incidence rate of the adverse events of hepatic arterial damage and leucopenia. No other serious complications were observed in either group.

CONCLUSION:

We conclude that TACE using a suspension of DDPH in LPD could be a useful treatment for HCC.

• Authors: Kazuhiro Kasai, Akira Ushio, Kei Sawara, Yasuhiro Miyamoto, Yukiho Kasai, Kanta Oikawa, Hidekatsu Kuroda, Yasuhiro Takikawa, Kazuyuki Suzuki
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 16 Issue 27 Pg. 3437-44 (Jul 21 2010) ISSN: 2219-2840 [Electronic] United States
• PMID: 20632449 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Dosage Forms
• Powders
• Cisplatin

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Carcinoma, Hepatocellular (drug therapy)
• Chemistry, Pharmaceutical
• Chemoembolization, Therapeutic
• Cisplatin (administration & dosage, therapeutic use)
• Disease-Free Survival
• Dosage Forms
• Female
• Humans
• Liver Neoplasms (drug therapy)
• Male
• Middle Aged
• Powders
• Treatment Outcome
• Young Adult