HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Vane's discovery of the mechanism of action of aspirin changed our understanding of its clinical pharmacology.

Abstract
Aspirin exerts its analgesic, antipyretic and anti-inflammatory actions by inhibiting the enzyme cyclooxygenase and thus preventing the formation and release of prostaglandins. The elucidation by John Vane of the mechanism of action of aspirin in 1971 was followed twenty years later by the discovery of a second cyclooxygenase enzyme, COX-2 and the rapid development of selective inhibitors of this enzyme. The COX-2 inhibitors are potent anti-inflammatory drugs without the damaging side effects on the stomach mucosa of the non-selective aspirin-like inhibitors. More recently, two enzymes have been identified inhibition of which may explain the mechanism of action of paracetamol. These are a putative cyclooxygenase-3 which is a variant of cyclooxygenase-1 and derives from the same gene, and a COX-2 variant, induced with diclofenac, which may be involved in the resolution of inflammation.
AuthorsRegina M Botting
JournalPharmacological reports : PR (Pharmacol Rep) 2010 May-Jun Vol. 62 Issue 3 Pg. 518-25 ISSN: 2299-5684 [Electronic] Switzerland
PMID20631416 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Diclofenac
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • Prostaglandin-Endoperoxide Synthases
  • cyclooxygenase-3
  • Aspirin
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Aspirin (pharmacology)
  • Cyclooxygenase 1 (genetics, metabolism)
  • Cyclooxygenase 2 (metabolism)
  • Cyclooxygenase 2 Inhibitors (pharmacology)
  • Cyclooxygenase Inhibitors (pharmacology)
  • Diclofenac (pharmacology)
  • Humans
  • Introns
  • Prostaglandin-Endoperoxide Synthases (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: