Etiopathology of
psoriasis is not completely understood. Patients with
psoriasis show elevated sensitivity to
gluten. The aim of this study was to see the expression of
celiac disease (CD)-associated
antibodies gliadin IgA,
gliadin IgG, and
tissue transglutaminase IgA, and their correlation with
HLA Cw6 in patients with
psoriasis. The study comprised 56 patients with
psoriasis and 60 healthy controls (HC). The levels of
antibodies were detected by using ELISA technique and
HLA Cw6 typing was carried out by microcytotoxicity method.
HLA Cw6 was significantly expressed in
psoriasis cases when compared with HC (P<0.05). CD-associated
antibodies gliadin IgA/
IgG and
tissue transglutaminase IgA were significantly higher in the serum of patient with
psoriasis when compared with HC (P<0.05, <0.05, and 0.01, respectively). Serum anti
tissue transglutaminase IgA (anti tTG IgA) was significantly higher in females when compared with males and expressed more in elderly patients. There was a significant positive correlation among the
antibodies (anti gliadin IgA with anti
gliadin IgG: r=0.67, P<0.05; anti
gliadin IgA with anti tTG
IgA: r=0.45, P<0.05, anti
gliadin IgG with anti tTG
IgA: r=0.26, P<0.05, respectively), whereas insignificant with
HLA Cw6. Our study concludes that latent CD or CD-associated
antibodies were present in patients with
psoriasis and also concludes that
HLA Cw6 has no association with expression of these
antibodies in patients with
psoriasis.