Reduction of ischemic and oxidative damage to the hypothalamus by hyperbaric oxygen in heatstroke mice.

Abstract

The aims of the present paper were to ascertain whether the heat-induced ischemia and oxidative damage to the hypothalamus and lethality in mice could be ameliorated by hyperbaric oxygen therapy. When normobaric air-treated mice underwent heat treatment, the fractional survival and core temperature at 4 hours after heat stress were found to be 0 of 12 and 34 degrees C +/- 0.3 degrees C, respectively. In hyperbaric oxygen-treated mice, when exposed to the same treatment, both fractional survival and core temperature values were significantly increased to new values of 12/12 and 37.3 degrees C +/- 0.3 degrees C, respectively. Compared to normobaric air-treated heatstroke mice, hyperbaric oxygen-treated mice displayed lower hypothalamic values of cellular ischemia and damage markers, prooxidant enzymes, proinflammatory cytokines, inducible nitric oxide synthase-dependent nitric oxide, and neuronal damage score. The data indicate that hyperbaric oxygen may improve outcomes of heatstroke by normalization of hypothalamic and thermoregulatory function in mice.

• Authors: Po-An Tai, Chen-Kuei Chang, Ko-Chi Niu, Mao-Tsun Lin, Wen-Ta Chiu, Jia-Wei Lin
• Journal: Journal of biomedicine & biotechnology (J Biomed Biotechnol) Vol. 2010 Pg. 609526 ( 2010) ISSN: 1110-7251 [Electronic] United States
• PMID: 20625500 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Inflammation Mediators
• Nitric Oxide Synthase Type II

Topics

• Animals
• Brain Ischemia (enzymology, etiology, pathology, therapy)
• Cytokines (metabolism)
• Extracellular Space (metabolism)
• Heat Stroke (complications, pathology, therapy)
• Hyperbaric Oxygenation
• Hypothalamus (enzymology, pathology)
• Inflammation Mediators (metabolism)
• Male
• Mice
• Mice, Inbred ICR
• Neurons (metabolism, pathology)
• Nitric Oxide Synthase Type II (metabolism)
• Oxidative Stress
• Survival Analysis