Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis.

Abstract

Bioactive glass (BAG)-S53P4 is an osteoconductive bone substitute with proven antibacterial and bone bonding properties. In a multicentre study 11 patients with verified chronic osteomyelitis in the lower extremity and the spine were treated with BAG-S53P4 as a bone substitute. The cavitary bone defect and the surrounding of a spinal implant were filled with BAG-S53P4. The most common pathogen causing the infection was Staphylococcus aureus. The mean follow-up was 24 months (range 10-38). BAG-S53P4 was well tolerated. Nine patients healed without complications. One patient who achieved good bone formation sustained a superficial wound infection due to vascular problems in the muscle flap, and one patient had an infection due to a deep haematoma. This study shows that BAG-S53P4 is a good and well-tolerated bone substitute, and can be used in treatment of osteomyelitis with good primary results.

• Authors: N C Lindfors, P Hyvönen, M Nyyssönen, M Kirjavainen, J Kankare, E Gullichsen, J Salo
• Journal: Bone (Bone) Vol. 47 Issue 2 Pg. 212-8 (Aug 2010) ISSN: 1873-2763 [Electronic] United States
• PMID: 20624692 (Publication Type: Journal Article)

Chemical References

• Bone Substitutes
• bioactive glass S53P4

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Bone Substitutes (therapeutic use)
• Bone Transplantation
• Female
• Glass (chemistry)
• Humans
• Male
• Middle Aged
• Mycobacterium tuberculosis (physiology)
• Osteomyelitis (diagnostic imaging, microbiology, surgery, therapy)
• Postoperative Care
• Radiography
• Spine (diagnostic imaging, microbiology, pathology)
• Staphylococcus aureus (physiology)
• Tibia (microbiology, pathology)