Essential oil from Citrus aurantifolia prevents ketotifen-induced weight-gain in mice.

Obesity is a major health problem world-wide. Medical intervention is often needed to tackle this problem, and accordingly the need for developing more effective, safer and cheaper weight reducing drugs has become paramount in recent years. In the present study, the effects of lime (Citrus aurantifolia) essential oils in reducing body weight, individually and in co-administration with ketotifen, an antihistaminic drug that causes weight gain, has been investigated using a mouse model. During the 45 days experimental period, the mice that received ketotifen demonstrated an enhancement both in the amount of food intake and body weight compared with the control group. Groups treated with lime essential oil displayed a reduction in body weight and food consumption in mice, possibly through promoting anorexia which might have played a role in weight loss. Interestingly, co-administration of the lime essential oil and ketotifen caused significant suppression in gaining weight, as well as decreased body weights of mice. The data obtained in this study suggested that lime essential oil plays an important role in weight loss and could be useful in the treatment of drug-induced obesity and related diseases. The GC-MS analysis of the essential oils of C. aurantifolia was also performed and approximately 22 main components, with limonene (28.27%) being the principal one, were identified and quantified.
AuthorsSolmaz Asnaashari, Abbas Delazar, Bohlol Habibi, Roghayeh Vasfi, Lutfun Nahar, Sanaz Hamedeyazdan, Satyajit D Sarker
JournalPhytotherapy research : PTR (Phytother Res) Vol. 24 Issue 12 Pg. 1893-7 (Dec 2010) ISSN: 1099-1573 [Electronic] England
PMID20623616 (Publication Type: Journal Article)
Chemical References
  • Cyclohexenes
  • Histamine H1 Antagonists
  • Oils, Volatile
  • Terpenes
  • limonene
  • Ketotifen
  • Animals
  • Citrus aurantiifolia (chemistry)
  • Cyclohexenes (chemistry)
  • Gas Chromatography-Mass Spectrometry
  • Histamine H1 Antagonists (adverse effects)
  • Ketotifen (adverse effects)
  • Male
  • Mice
  • Obesity (prevention & control)
  • Oils, Volatile (chemistry, pharmacology)
  • Terpenes (chemistry)
  • Weight Gain (drug effects)

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