Abstract |
The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.
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Authors | Isao Kubo, Teruhiko Nitoda, Felismino E Tocoli, Ivan R Green |
Journal | Phytotherapy research : PTR
(Phytother Res)
Vol. 25
Issue 1
Pg. 38-45
(Jan 2011)
ISSN: 1099-1573 [Electronic] England |
PMID | 20623613
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 John Wiley & Sons, Ltd. |
Chemical References |
- Anacardic Acids
- Cytotoxins
- Melanins
- Resorcinols
- Monophenol Monooxygenase
- adipostatin A
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Topics |
- Anacardic Acids
(chemistry, isolation & purification, pharmacology)
- Anacardium
(chemistry)
- Animals
- Cytotoxins
(chemistry, isolation & purification, pharmacology)
- Melanins
(biosynthesis)
- Melanocytes
(drug effects)
- Melanoma
(pathology)
- Mice
- Monophenol Monooxygenase
(antagonists & inhibitors)
- Resorcinols
(chemistry, isolation & purification, pharmacology)
- Tumor Cells, Cultured
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