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Multifunctional cytotoxic agents from Anacardium occidentale.

Abstract
The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.
AuthorsIsao Kubo, Teruhiko Nitoda, Felismino E Tocoli, Ivan R Green
JournalPhytotherapy research : PTR (Phytother Res) Vol. 25 Issue 1 Pg. 38-45 (Jan 2011) ISSN: 1099-1573 [Electronic] England
PMID20623613 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 John Wiley & Sons, Ltd.
Chemical References
  • Anacardic Acids
  • Cytotoxins
  • Melanins
  • Resorcinols
  • Monophenol Monooxygenase
  • adipostatin A
Topics
  • Anacardic Acids (chemistry, isolation & purification, pharmacology)
  • Anacardium (chemistry)
  • Animals
  • Cytotoxins (chemistry, isolation & purification, pharmacology)
  • Melanins (biosynthesis)
  • Melanocytes (drug effects)
  • Melanoma (pathology)
  • Mice
  • Monophenol Monooxygenase (antagonists & inhibitors)
  • Resorcinols (chemistry, isolation & purification, pharmacology)
  • Tumor Cells, Cultured

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