Abstract | BACKGROUND: OBJECTIVE: To optimize antiarrhythmic therapy in recessively inherited CPVT caused by calsequestrin (CASQ2) mutations. METHODS: Murine heart rhythm telemetry was obtained at rest, during treadmill exercise, and after injection of epinephrine. The protocol was repeated after injection of different antiarrhythmic drugs. Results were then validated in human patients. RESULTS: CONCLUSION:
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Authors | Guy Katz, Assad Khoury, Efrat Kurtzwald, Edith Hochhauser, Eyal Porat, Asher Shainberg, Jonathan G Seidman, Christine E Seidman, Abraham Lorber, Michael Eldar, Michael Arad |
Journal | Heart rhythm
(Heart Rhythm)
Vol. 7
Issue 11
Pg. 1676-82
(Nov 2010)
ISSN: 1556-3871 [Electronic] United States |
PMID | 20620233
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Arrhythmia Agents
- Propranolol
- Verapamil
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Topics |
- Adolescent
- Adult
- Animals
- Anti-Arrhythmia Agents
(therapeutic use)
- Child
- Female
- Humans
- Male
- Mice
- Mice, Transgenic
- Propranolol
(therapeutic use)
- Tachycardia, Ventricular
(drug therapy)
- Treatment Outcome
- Verapamil
(therapeutic use)
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