Talin 2 concentrations in cerebrospinal fluid in patients with epilepsy.

Abstract

OBJECTIVES:

Talin 2 plays an important role in cell adhesion and recycling of synaptic vesicles. To explore the possible role of talin 2 in epilepsy, we designed current study to quantitatively evaluate the changes in talin 2 levels in different epilepsy patients.

DESIGN AND METHODS:

We measured talin 2 levels in CSF and the serum of postencephalitic epilepsy (PEE) patients (subdivided into drug-refractory PEE-RPEE, and drug-effective PEE-EPEE groups) and acute encephalitis patients (subdivided into acute encephalitis with secondary seizures-AESS, and acute encephalitis without seizures-AE) by enzyme-linked immunosorbent assay.

RESULTS:

We found that, in RPEE patients, interictal CSF-talin 2 concentrations significantly increased, whereas serum-talin 2 significantly decreased when compared with the AE, AESS, and EPEE groups.

CONCLUSIONS:

This result suggested that the differential concentration of CSF and serum-talin 2 in the RPEE group is an intractability-related phenomenon that might be involved in the development of RPEE.

• Authors: Zheng Xiao, Lan Shen, Dan Chen, Liang Wang, Zhiqin Xi, Fei Xiao, Xuefeng Wang
• Journal: Clinical biochemistry (Clin Biochem) Vol. 43 Issue 13-14 Pg. 1129-32 (Sep 2010) ISSN: 1873-2933 [Electronic] United States
• PMID: 20620133 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Chemical References

• TLN2 protein, human
• Talin

Topics

• Adolescent
• Adult
• Child
• Drug Resistance
• Encephalitis (cerebrospinal fluid)
• Epilepsy (cerebrospinal fluid)
• Female
• Humans
• Male
• Middle Aged
• Seizures (cerebrospinal fluid)
• Talin (blood, cerebrospinal fluid)
• Young Adult