Impact of walking on adipose tissue lipoprotein lipase activity and expression in pre- and postmenopausal women.

Abstract

OBJECTIVE:

The aim of this study was to examine regional variation in adipose tissue lipoprotein lipase (AT-LPL) activity and expression in pre-and postmenopausal women, before and after training, once differences in chronological age or obesity degree are taken into account.

METHODS:

Sixteen late pre- and 14 early postmenopausal (49 +/- 2 vs. 52 +/- 2 years; p < 0.001) moderately obese women (body mass index 29-35 kg/m(2)) were subjected to a 16-week walking program (3 sessions/week of 45 min at 60% heart rate reserve). Abdominal and femoral AT-LPL activity and expression, fasting lipid-lipoprotein profile, body composition, and cardiorespiratory fitness (CRF) were measured before and after our intervention. Statistical analyses were performed using covariance analysis for age differences.

RESULTS:

AT-LPL activity and expression, lipid-lipoprotein metabolism, body fatness, and CRF were similar at baseline, irrespective of the group considered. Slight reductions in plasma cholesterol and high-density lipoprotein (HDL) cholesterol levels, fat mass and waist girth reductions, CRF increases as well as femoral AT-LPL activity and expression decreases after our intervention were comparable, regardless of menopausal status (0.0001 < p < 0.05).

CONCLUSIONS:

Lipid storage is decreased in the femoral depot after walking, regardless of menopausal status. Reduction in AT-LPL activity or expression does not lead to a more deleterious lipid-lipoprotein profile, despite the modest decrease noted in HDL cholesterol concentrations.

• Authors: Sebastien Tessier, Eléonor Riesco, Michel Lacaille, Francine Pérusse, John Weisnagel, Jean Doré, Pascale Mauriège
• Journal: Obesity facts (Obes Facts) Vol. 3 Issue 3 Pg. 191-9 (Jun 2010) ISSN: 1662-4025 [Print] Switzerland
• PMID: 20616609 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2010 S. Karger AG, Basel.

Chemical References

• Cholesterol, HDL
• Lipoproteins, LDL
• RNA, Messenger
• Estradiol
• Follicle Stimulating Hormone
• Lipoprotein Lipase

Topics

• Abdominal Fat (enzymology)
• Cholesterol, HDL (blood)
• Enzyme Activation (physiology)
• Estradiol (blood)
• Exercise (physiology)
• Female
• Follicle Stimulating Hormone (blood)
• Gene Expression Regulation, Enzymologic
• Humans
• Lipoprotein Lipase (genetics, metabolism)
• Lipoproteins, LDL (blood)
• Middle Aged
• Postmenopause (metabolism)
• Premenopause (metabolism)
• RNA, Messenger (metabolism)
• Subcutaneous Fat (enzymology)
• Thigh
• Walking (physiology)