Cancer cell specific gene delivery by laminin-derived peptide AG73-labeled liposomes.

Abstract

We developed laminin-derived AG73 peptide labeled liposomes for cancer specific gene therapy. AG73 peptide is well known as a ligand for syndecan-2 which is highly expressed in various cancer cells. Liposomes labeled with AG73 showed high efficient transfection efficiency in syndecan-2 overexpressing cells, and found that AG73 could be a superior molecule in the development of non-viral vector using liposomes for the gene delivery to syndecan-2 overexpressing cancer cells.

• Authors: Hiroshi Iijima, Yoichi Negishi, Daiki Omata, Motoyoshi Nomizu, Yukihiko Aramaki
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 20 Issue 15 Pg. 4712-4 (Aug 01 2010) ISSN: 1464-3405 [Electronic] England
• PMID: 20615691 (Publication Type: Journal Article)
• Copyright: Copyright 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Laminin
• Liposomes
• Peptides
• Syndecan-2

Topics

• Amino Acid Sequence
• Antineoplastic Agents (administration & dosage, chemistry)
• Cell Line
• Humans
• Laminin (chemistry)
• Liposomes (chemistry)
• Molecular Sequence Data
• Neoplasms (therapy)
• Peptides (administration & dosage, chemistry)
• Syndecan-2 (antagonists & inhibitors, metabolism)
• Transfection