Abstract |
Strictinin, which is a member of the ellagitanin family of hydrolyzable tannins, prevented replication of human, duck and swine influenza A viruses (IAVs) in vitro at non-toxic concentrations. The addition of strictinin at the same time as IAV inoculation to MDCK cells inhibited viral replication in a dose-dependent manner. Strictinin showed 50% inhibitory concentrations for IAVs from 0.09±0.021 to 0.28±0.037μM (mean±S.E.M.) by the focus-forming assay. Treatment of MDCK cells with strictinin before and after viral inoculation resulted in no significant antiviral activity. Further studies showed that strictinin inhibited IAV-induced hemifusion. However, strictinin exhibited no inhibitory effect against receptor binding, sialidase activity. Strictinin also showed an antiviral effect on influenza B virus and human parainfluenza virus type-1 in vitro. The results indicate that strictinin is a useful antiviral agent.
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Authors | Repon Kumer Saha, Tadanobu Takahashi, Yuuki Kurebayashi, Keijo Fukushima, Akira Minami, Noriaki Kinbara, Masaki Ichitani, Yuko M Sagesaka, Takashi Suzuki |
Journal | Antiviral research
(Antiviral Res)
Vol. 88
Issue 1
Pg. 10-8
(Oct 2010)
ISSN: 1872-9096 [Electronic] Netherlands |
PMID | 20615432
(Publication Type: Journal Article)
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Copyright | Copyright © 2010 Elsevier B.V. All rights reserved. |
Chemical References |
- Antiviral Agents
- Phenols
- Tannins
- strictinin
- Neuraminidase
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Topics |
- Animals
- Antiviral Agents
(pharmacology)
- Cell Line
- Dose-Response Relationship, Drug
- Humans
- Influenza A virus
(drug effects, physiology)
- Influenza B virus
(drug effects, physiology)
- Neuraminidase
(antagonists & inhibitors)
- Parainfluenza Virus 1, Human
(drug effects, physiology)
- Phenols
(pharmacology)
- Tannins
(pharmacology)
- Virus Attachment
(drug effects)
- Virus Replication
(drug effects)
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