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Cerebral hemodynamic responses to seizure in the mouse brain: simultaneous near-infrared spectroscopy-electroencephalography study.

Abstract
We applied near-infrared spectroscopy (NIRS) and electroencephalography (EEG) simultaneously on the mouse brain and investigated the hemodynamic response to epileptic episodes under pharmacologically driven seizure. gamma-butyrolactone (GBL) and 4-aminopyridine (4-AP) were applied to induce absence and tonic-clonic seizures, respectively. The epileptic episodes were identified from the single-channel EEG, and the corresponding hemodynamic changes in different regions of the brain were characterized by multichannel frequency-domain NIRS. Our results are the following: (i) the oxyhemoglobin level increases in the case of GBL-treated mice but not 4-AP-treated mice compared to the predrug state; (ii) the dominant response to each absence seizure is a decrease in deoxyhemolobin; (iii) the phase shift between oxy- and deoxyhemoglobin reduces in GBL-treated mice but no 4-AP-treated mice; and (iv) the spatial correlation of hemodynamics increased significantly in 4-AP-treated mice but not in GBL-treated mice. Our results shows that spatiotemporal tracking of cerebral hemodynamics using NIRS can be successfully applied to the mouse brain in conjunction with electrophysiological recording, which will support the study of molecular, cellular, and network origin of neurovascular coupling in vivo.
AuthorsSeungduk Lee, Mina Lee, Dalkwon Koh, Beop-Min Kim, Jee Hyun Choi
JournalJournal of biomedical optics (J Biomed Opt) 2010 May-Jun Vol. 15 Issue 3 Pg. 037010 ISSN: 1560-2281 [Electronic] United States
PMID20615039 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Hemoglobins
  • Oxyhemoglobins
  • deoxyhemoglobin
  • 4-Aminopyridine
  • 4-Butyrolactone
Topics
  • 4-Aminopyridine (pharmacology)
  • 4-Butyrolactone (pharmacology)
  • Animals
  • Brain (blood supply, drug effects, metabolism, physiopathology)
  • Electroencephalography (drug effects)
  • Epilepsy (chemically induced, metabolism, physiopathology)
  • Female
  • Hemodynamics (drug effects)
  • Hemoglobins (metabolism)
  • Mice
  • Mice, Inbred ICR
  • Oxyhemoglobins (metabolism)
  • Signal Processing, Computer-Assisted
  • Spectroscopy, Near-Infrared (methods)

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