Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in three Malay children.

Abstract

Citrin deficiency is an autosomal recessive disorder caused by mutation in the SLC25AJ3 gene. It has two major phenotypes: adult-onset type II citrullinemia (CTLN2) and neonatal intrahepatic cholestatic caused by citrin deficiency (NICCD). NICCD is characterized by neonatal/infantile-onset cholestatic hepatitis syndrome associated with multiple amino acidemia and hypergalactosemia. NICCD is self-limiting in most patients. However, some patients may develop CTLN2 years later, which manifests as fatal hyperammonemia coma. We report three unrelated Malay children with genetically confirmed NICCD characterised by an insertion mutation IVS16ins3kb in SLC25A13 gene. All 3 patients presented with prolonged neonatal jaundice which resolved without specific treatment between 5 to 10 months. Of note was the manifestation of a peculiar dislike of sweet foods and drinks. Elevated plasma citrulline was an important biochemical marker. NICCD should be considered in the differential diagnosis of cholestatic jaundice in Malaysian infants regardless of ethnic origin.

• Authors: Hock Lock Ngu, Md Yunus Zabedah, Keiko Kobayashi
• Journal: The Malaysian journal of pathology (Malays J Pathol) Vol. 32 Issue 1 Pg. 53-7 (Jun 2010) ISSN: 0126-8635 [Print] Malaysia
• PMID: 20614727 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mitochondrial Membrane Transport Proteins
• SLC25A13 protein, human
• Citrulline

Topics

• Child
• Child, Preschool
• Cholestasis, Intrahepatic (genetics, metabolism)
• Citrulline (blood)
• Citrullinemia (complications, genetics)
• Female
• Humans
• Infant
• Infant, Newborn
• Infant, Newborn, Diseases (genetics)
• Malaysia
• Male
• Mitochondrial Membrane Transport Proteins (deficiency, genetics)
• Mutagenesis, Insertional
• Polymerase Chain Reaction