Abstract | OBJECTIVES: METHODS: RESULTS: In both animal models, riociguat treatment improved survival and normalized blood pressure. Moreover, in the L-NAME study part, riociguat reduced cardiac target organ damage as indicated by lower plasma ANP, lower relative left ventricular weight and lower cardiac interstitial fibrosis, and reduced renal target organ damage as indicated by lower plasma creatinine and urea, less glomerulosclerosis and less renal interstitial fibrosis. In the 5/6 nephrectomy study part, riociguat reduced cardiac target organ damage as indicated by lower plasma ANP, lower relative left ventricular weight, lower myocyte diameter and lower arterial media/lumen ratio, and reduced renal target organ damage as indicated by improved creatinine clearance and less renal interstitial fibrosis. CONCLUSION: We demonstrate for the first time that the novel sGC stimulator riociguat shows in two independent models of hypertension a potent protection against cardiac and renal target organ damage.
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Authors | Yuliya Sharkovska, Philipp Kalk, Bettina Lawrenz, Michael Godes, Linda Sarah Hoffmann, Kathrin Wellkisch, Sandra Geschka, Katharina Relle, Berthold Hocher, Johannes-Peter Stasch |
Journal | Journal of hypertension
(J Hypertens)
Vol. 28
Issue 8
Pg. 1666-75
(Aug 2010)
ISSN: 1473-5598 [Electronic] England |
PMID | 20613628
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Pyrazoles
- Pyrimidines
- Nitric Oxide
- Renin
- Guanylate Cyclase
- riociguat
- NG-Nitroarginine Methyl Ester
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Topics |
- Animals
- Animals, Genetically Modified
- Antihypertensive Agents
(pharmacology)
- Disease Models, Animal
- Disease Progression
- Dose-Response Relationship, Drug
- Guanylate Cyclase
(antagonists & inhibitors, metabolism)
- Heart
(drug effects)
- Hypertension
(chemically induced, enzymology, prevention & control)
- Kidney
(drug effects, pathology)
- Longevity
(drug effects)
- Male
- Muscle Contraction
(drug effects)
- Muscle, Smooth, Vascular
(drug effects)
- Myocardium
(pathology)
- NG-Nitroarginine Methyl Ester
(toxicity)
- Nephrectomy
- Nephritis, Interstitial
(chemically induced, pathology, prevention & control)
- Nitric Oxide
(metabolism)
- Pyrazoles
(pharmacology)
- Pyrimidines
(pharmacology)
- Rabbits
- Rats
- Rats, Wistar
- Renin
(drug effects, physiology)
- Signal Transduction
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