Considerations on implementing diagnostic markers into clinical decision making in bladder cancer.
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| Abstract |
Bladder cancer is a common disease that is often detected late and has a high rate of recurrence and progression. Cystoscopy is the main tool in detection and surveillance of bladder cancer but is invasive and can miss some cancers. Cytology is frequently utilized but suffers from a poor sensitivity. There are several commercially available urine-based tumor markers currently available but their use is not recommended by guideline panels. Markers such as the Urovysion FISH assay and the NMP22 BladderChek test are approved for surveillance and detection in patients with hematuria. The added benefit of these markers and other commercially available markers (e.g. Ucyt+, BTA stat) has not been well investigated though it appears these markers are insufficiently sensitive to replace cystoscopy. Additional studies are needed to determine the clinical scenarios where bladder markers are best utilized (screening, surveillance, early detection, evaluating cytologic atypia) and what impact they should have on clinical decision making. Furthermore, a variety of issues and barriers can affect the movement of clinical tests from research to clinical practice. This article addresses some of the challenges facing research and medical communities in the delivery and integration of markers for bladder cancer diagnosis. Moreover, we attempt to outline criteria for the clinical utility of new bladder cancer diagnostic markers.
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| Authors | Yair Lotan, Shahrokh F Shariat, Bernd J Schmitz-Dräger, Marta Sanchez-Carbayo, Feliksas Jankevicius, Marco Racioppi, Sarah J P Minner, Brigitte Stöhr, Pier Francesco Bassi, H Barton Grossman |
| Journal | Urologic oncology (Urol Oncol) 2010 Jul-Aug Vol. 28 Issue 4 Pg. 441-8 ISSN: 1873-2496 [Electronic] United States |
| PMID | 20610281 (Publication Type: Journal Article) |
| Copyright | Copyright 2010 Elsevier Inc. All rights reserved. |
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