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Early monitoring of external radiation therapy by [18F]-fluoromethylcholine positron emission tomography and 3-T proton magnetic resonance spectroscopy: an experimental study in a rodent rhabdomyosarcoma model.

AbstractPURPOSE:
To assess early radiation therapy (RT)-induced variations in total choline (tCho) concentration measured by proton magnetic resonance spectroscopy (H-MRS) and in (18)F-labelled fluoromethylcholine (FCH) uptake measured by PET in a rodent tumour model.
METHODS:
Nine rats bearing syngenic rhabdomyosarcoma grafts in both thighs were irradiated (13 Gy, one fraction). H-MRS data and FCH-PET were acquired in the same imaging session prior to and 3, 9 and 16 days after external RT. Total choline concentration was expressed in arbitrary units as the area under the curve of the 3.2-ppm peak on H-MR spectra. FCH uptake was expressed as maximum standardized uptake value (SUV(max)) and as the % of injected dose per gram (%ID/g) after precise tumour delineation on hybrid PET-MR images. Pre- and post-RT data were compared using the Student's paired t test, and results were expressed as mean+/-S.D.
RESULTS:
Seventeen tumours were available for analysis. A mean drop in choline concentration of 45% was observed 3 days after irradiation (P<.001), whereas a concomitant mean increase in SUV(max) of 41% was observed (P=.006). Choline concentration reincreased on later time points.
CONCLUSIONS:
Opposite trend between increased FCH uptake and decreased tCho peak was observed at 3 days. Later (9 and 16 days), uptake remained stable and tCho peak reincreased.
AuthorsDenis Rommel, Jorge Abarca-Quinones, Anne Bol, Frank Peeters, Renaud Lhommel, Max Lonneux, Daniel Labar, Vincent Gregoire, Thierry Duprez
JournalNuclear medicine and biology (Nucl Med Biol) Vol. 37 Issue 5 Pg. 645-53 (Jul 2010) ISSN: 1872-9614 [Electronic] United States
PMID20610169 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2010 Elsevier Inc. All rights reserved.
Chemical References
  • Alginates
  • Hexuronic Acids
  • Protons
  • fluoromethylcholine
  • Glucuronic Acid
  • Choline
Topics
  • Alginates (metabolism)
  • Animals
  • Biological Transport
  • Choline (analogs & derivatives, metabolism)
  • Disease Models, Animal
  • Glucuronic Acid (metabolism)
  • Hexuronic Acids (metabolism)
  • Magnetic Resonance Spectroscopy (methods)
  • Male
  • Positron-Emission Tomography
  • Protons
  • Rats
  • Rhabdomyosarcoma (diagnostic imaging, metabolism, pathology, radiotherapy)
  • Survival Rate
  • Time Factors
  • Treatment Outcome

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