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The molecular biology of myeloproliferative disorders.

Abstract
The myeloproliferative disorders (MPDs) are a spectrum of clonal disorders of the hematopoietic system. The discovery of activating mutations of the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and primary myelofibrosis has lead to in vitro and animal model studies that promise to lead to therapeutic advances.
AuthorsJerald Radich
JournalCancer cell (Cancer Cell) Vol. 18 Issue 1 Pg. 7-8 (Jul 13 2010) ISSN: 1878-3686 [Electronic] United States
PMID20609348 (Publication Type: Comment, Journal Article)
CopyrightCopyright (c) 2010 Elsevier Inc. All rights reserved.

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