Antitubercular resorcinol analogs and benzenoid C-glucoside from the roots of Ardisia cornudentata.

Abstract

Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1'-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis of spectroscopic data. Thirteen of these isolates, 1, 2, 4- 6, 9- 15, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37R (V) IN VITRO, with MIC values of 2.5-60 µg/mL. Two alkyl benzoquinones, ardisianone (7) and cornudentanone ( 8), were reported for their selective cytotoxic activity against the NCI-H460 cancer cell line (IC (50) values of 2.3, 2.5 µg/mL).

• Authors: Chun-Po Chang, Hsun-Shuo Chang, Chien-Fang Peng, Shiow-Ju Lee, Ih-Sheng Chen
• Journal: Planta medica (Planta Med) Vol. 77 Issue 1 Pg. 60-5 (Jan 2011) ISSN: 1439-0221 [Electronic] Germany
• PMID: 20607650 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Antitubercular Agents
• Benzoquinones
• Resorcinols
• resorcinol

Topics

• Antitubercular Agents (chemistry, isolation & purification, pharmacology)
• Ardisia (chemistry)
• Benzoquinones (chemistry, isolation & purification, pharmacology)
• Cell Line, Tumor
• Chemical Fractionation
• Humans
• Inhibitory Concentration 50
• Microbial Sensitivity Tests
• Mycobacterium tuberculosis (drug effects)
• Plant Roots (chemistry)
• Resorcinols (chemistry, isolation & purification, pharmacology)