Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia.

Abstract

Mild to moderately severe Pneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole. The results revealed that primaquine/clindamycin appears to be an equally effective alternative to trimethoprim/sulfamethoxazole. The spectrum of side-effects was similar for the two regimens; side-effects occurred with equal frequency but appeared to be less severe in patients given primaquine/clindamycin. Because therapy with primaquine and clindamycin was limited to patients with mild to moderate Pneumocystis carinii pneumonia, studies with this regimen in more severe cases are warranted.

• Authors: B Ruf, I Rohde, H D Pohle
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 10 Issue 3 Pg. 207-10 (Mar 1991) ISSN: 0934-9723 [Print] Germany
• PMID: 2060533 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Clindamycin
• Trimethoprim, Sulfamethoxazole Drug Combination
• Primaquine

Topics

• Acquired Immunodeficiency Syndrome (complications)
• Adult
• Clindamycin (adverse effects, therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Male
• Middle Aged
• Pneumonia, Pneumocystis (drug therapy)
• Primaquine (adverse effects, therapeutic use)
• Trimethoprim, Sulfamethoxazole Drug Combination (adverse effects, therapeutic use)