[Combination of methotrexate injection through hysteroscopic tubal catheterization and mifepristone per os in the conservative treatment of tubal pregnancy].

Abstract

OBJECTIVE:

To evaluate the value of the combination of methotrexate(MTX) injection through hysteroscopic tubal catheterization and mifepristone per os in the conservative treatment of tubal pregnancy.

METHODS:

Forty patients who met the criteria of conservative treatment were enrolled in this study and received the combined therapy of MTX 50 mg/d injection through hysteroscopic tubal catheterization and oral mifepristone 100mg/d for 5 days.

RESULTS:

Of these 40 patients, 38 (95.0%) were cured. The human chorionic gonadotropin decreased to normal level within 3-48 days. The masses disappeared within 16-65 days. The menstruation returned normal within 28-42 days. No obvious side effect was observed. Of 30 patients who underwent hydrotubation through hysteroscopy three months later, 12 patients were unobstructed, 2 patients were completely obstructed, and 16 patients were partially obstructed. Five patients had full-term deliveries up to this report.

CONCLUSION:

The combination of MTX injection through hysteroscopic tubal catheterization and mifepristone per os is safe and effective for early tubal pregnancy.

• Authors: Hui Zhao, Bao-Jun Yang, Li-Min Feng
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 32 Issue 3 Pg. 315-9 (Jun 2010) ISSN: 1000-503X [Print] China
• PMID: 20602886 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Mifepristone
• Methotrexate

Topics

• Adult
• Drug Therapy, Combination
• Female
• Humans
• Hysteroscopy
• Injections
• Methotrexate (administration & dosage, therapeutic use)
• Mifepristone (therapeutic use)
• Pregnancy
• Pregnancy, Tubal (drug therapy)
• Young Adult