The interface between transcription and mRNP export: from THO to THSC/TREX-2.

Abstract

Eukaryotic gene expression is a multilayer process covering transcription to post-translational protein modifications. As the nascent pre-mRNA emerges from the RNA polymerase II (RNAPII), it is packed in a messenger ribonucleoparticle (mRNP) whose optimal configuration is critical for the normal pre-mRNA processing and mRNA export, mRNA integrity as well as for transcription elongation efficiency. The interplay between transcription and mRNP formation feeds forward and backward and involves a number of conserved factors, from THO to THSC/TREX-2, which in addition have a unique impact on transcription-dependent genome instability. Here we review our actual knowledge of the role that these factors play at the interface between transcription and mRNA export in the model organism Saccharomyces cerevisiae.

• Authors: Ana G Rondón, Sonia Jimeno, Andrés Aguilera
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1799 Issue 8 Pg. 533-8 (Aug 2010) ISSN: 0006-3002 [Print] Netherlands
• PMID: 20601280 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Cell Cycle Proteins
• DNA-Binding Proteins
• Nuclear Proteins
• Phosphoproteins
• RNA-Binding Proteins
• Ribonucleoproteins
• THOC1 protein, human
• messenger ribonucleoprotein
• Exodeoxyribonucleases
• TREX2 protein, human

Topics

• Cell Cycle Proteins (genetics, metabolism)
• DNA-Binding Proteins
• Exodeoxyribonucleases (genetics, metabolism)
• Humans
• Nuclear Proteins (genetics, metabolism)
• Phosphoproteins (genetics, metabolism)
• RNA Transport
• RNA-Binding Proteins
• Ribonucleoproteins (genetics, metabolism)
• Transcription, Genetic