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Probiotic administration effect on fecal mutagenicity and microflora in the goat's gut.

Abstract
The application of potentially beneficial microorganisms to increase host defense is a new trend to increase health benefits. In this paper the first specific host probiotics for goats from a mixture isolated from healthy animals (Lactobacillus reuteri DDL 19, Lactobacillus alimentarius DDL 48, Enterococcus faecium DDE 39 and Bifidobacterium bifidum DDBA) was assayed. The effect of probiotic oral administration on goats' weight, gut microbiota, as well as on the production of mutagen compounds and their indicator (putrescine), were evaluated. The probiotic supplement was able to modify microflora balance by reducing Enterobacteria like Salmonella/Shigella (1.09 and 1.21 log CFU/g feces, respectively) and increasing lactic acid bacteria and Bifidobacteria (1.67 and 2.34 log CFU/g feces, respectively). The probiotics administration was correlated with a ten time diminution of fecal putrescine (cancer and bacterial disease marker) and a decrease of 60% mutagen fecal concentration, indicating the protective effect of the treatment. Additionally, a significant increase in ruminant weight was observed after probiotic administration. These results are encouraging towards the use of probiotic mixtures as functional food for goats.
AuthorsAna Lidia Apás, Javier Dupraz, Romina Ross, Silvia Nelina González, Mario Eduardo Arena
JournalJournal of bioscience and bioengineering (J Biosci Bioeng) Vol. 110 Issue 5 Pg. 537-40 (Nov 2010) ISSN: 1347-4421 [Electronic] Japan
PMID20598940 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Mutagens
  • Putrescine
Topics
  • Administration, Oral
  • Animals
  • Bacterial Load
  • Biotechnology
  • Feces (chemistry, microbiology)
  • Gastrointestinal Tract (metabolism, microbiology)
  • Goats (metabolism, microbiology)
  • Metagenome
  • Mutagens (metabolism)
  • Probiotics (administration & dosage)
  • Putrescine (metabolism)

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