Immunology plays a crucial role in establishing successful pregnancy. This is primarily due the recognition of fetal
antigen and alteration of the immune response mounted by the mother. It is therefore easy to understand the importance of testing for immune causes of reproductive failure and offer immune
therapy to those with abnormal immune response. The main difficulty with this model is the understanding of what is normal, which is still under study, and then to test for abnormality. It is only after these two questions are answered that we can consider the use of
immunotherapy in women with immune causes of reproductive failure. This review looks at the current available information on the immunology surrounding reproductive failure and the current
therapies offered to rectify these abnormalities. Till date numerous studies have looked into the role of various immune suppressant modulatory
therapies in women with
recurrent miscarriage or implantation failure after assisted conception and have suggested that there is a place for immune
therapy in reproductive failure. However the search for best evidence is still on and randomized, blinded data with adequate sample size is lacking. Till such time that it becomes available, immune testing and
immunotherapy should be offered within the realms of a research setting.