Gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI versus gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI for preoperatively detecting hepatocellular carcinoma: an initial experience.

Abstract

OBJECTIVE:

This study was designed to compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (MRI) with gadobenate dimeglumine-enhanced MRI for preoperatively detecting hepatocellular carcinoma (HCC).

MATERIALS AND METHODS:

Eighteen consecutive patients (17 men and one woman, age range: 31-73 years) with 22 HCCs underwent examinations with gadoxetic acid enhanced MRI and gadobenate dimeglumine-enhanced MRI on a 3.0-Tesla unit. The diagnosis of HCC was established after surgical resection and pathological conformation. Three observers independently reviewed each MR image in a random order on a tumor-by-tumor basis. The diagnostic accuracy of these techniques for the detection of HCC was assessed by performing an alternative free-response receiver operating characteristic (ROC) analysis. The sensitivity and positive predictive values were evaluated.

RESULTS:

The average value of the area under the ROC curve (Az) for gadoxetic acid enhanced MRI (0.887) was not significantly different from the Az (0.899) for gadobenate dimeglumine-enhanced MRI (p > 0.05). The overall sensitivities of gadoxetic acid enhanced MRI and gadobenate dimeglumine-enhanced MRI were 80% and 83%, respectively, with no significant difference (p > 0.05). The differences of the positive predictive values for the two contrast agents for each observer were not statistically significant (p > 0.05).

CONCLUSION:

The diagnostic performance of gadoxetic acid-enhanced MRI and gadobenate dimeglumine-enhanced MRI for preoperatively detecting HCC is quite similar.

• Authors: Yulri Park, Seong Hyun Kim, Seung Hoon Kim, Yong Hwan Jeon, Jongmee Lee, Min Ju Kim, Dongil Choi, Won Jae Lee, Heejung Kim, Ji Hyun Koo, Hyo Keun Lim
• Journal: Korean journal of radiology (Korean J Radiol) 2010 Jul-Aug Vol. 11 Issue 4 Pg. 433-40 ISSN: 2005-8330 [Electronic] Korea (South)
• PMID: 20592927 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Organometallic Compounds
• gadolinium ethoxybenzyl DTPA
• gadobenic acid
• Meglumine
• Gadolinium DTPA

Topics

• Adult
• Aged
• Carcinoma, Hepatocellular (diagnosis)
• Female
• Gadolinium DTPA
• Humans
• Image Interpretation, Computer-Assisted
• Liver Neoplasms (diagnosis)
• Magnetic Resonance Imaging (methods)
• Male
• Meglumine (analogs & derivatives)
• Middle Aged
• Organometallic Compounds
• Predictive Value of Tests
• ROC Curve
• Sensitivity and Specificity
• Statistics, Nonparametric