Abstract | OBJECTIVE: PATIENTS AND METHODS: 39 patients (8 female, 31 male) with advanced head and neck cancer were included in a randomised phase II study. The mean age was 63.52+/-9.31 years. Tumour localizations: oral cavity 15 patients, oropharynx 19 patients, hypopharynx 5 patients, carcinoma of unknown primary 1 patient. Group A (n=22) received 500 microg sodium selenite on the days of radiotherapy and 300 microg sodium selenite on days without radiotherapy. Group B (17) was irradiated without any selenium substitution. Both groups were well balanced according to age, gender, localization and stage of the tumour. The RTOG grade of radiation-associated toxicities was evaluated once per week. RESULTS: The following serious toxicities were observed (group A vs. group B): dysphagia 22.7% vs. 35.3%, loss of taste 22.7% vs. 47.1%, dry mouth 22.7% vs. 23.5%, and stomatitis 36.4% vs. 23.5%. A statistical trend (Fisher's exact test) was only seen for the loss of taste (p=0.172). The weekly patient analysis (Student's t-test) showed a significant reduction of dysphagia in the selenium group (Group 1) at the last week of irradiation. CONCLUSION:
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Authors | J Büntzel, D Riesenbeck, M Glatzel, R Berndt-Skorka, T Riedel, R Mücke, K Kisters, K G Schönekaes, U Schäfer, F Bruns, O Micke |
Journal | Anticancer research
(Anticancer Res)
Vol. 30
Issue 5
Pg. 1829-32
(May 2010)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 20592387
(Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Aged
- Carcinoma, Squamous Cell
(radiotherapy)
- Deglutition Disorders
(pathology, prevention & control)
- Female
- Head and Neck Neoplasms
(radiotherapy)
- Humans
- Male
- Medical Oncology
(methods)
- Middle Aged
- Mucositis
(prevention & control)
- Radiation Injuries
(pathology, prevention & control)
- Sodium Selenite
(pharmacology)
- Xerostomia
(prevention & control)
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