Increased levels of 8-hydroxydeoxyguanosine in the vitreous of patients with diabetic retinopathy.

Abstract

We determined the intravitreous level of 8-hydroxydeoxyguanosine (8-OHdG) in diabetic retinopathy (DR) and analyzed the relation between oxidative stress and DR. Vitreous 8-OHdG concentration increased significantly in 18 patients (20 eyes) with DR compared with controls with macular disease. This result suggests that increased oxidative stress is involved in DR.

• Authors: Yoshihiro Wakabayashi, Yoshihiko Usui, Yusuke Shibauchi, Hiroyuki Uchino, Hiroshi Goto
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 89 Issue 3 Pg. e59-61 (Sep 2010) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 20591522 (Publication Type: Journal Article)
• Copyright: Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• 8-Hydroxy-2'-Deoxyguanosine
• Deoxyguanosine

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• Aged
• Deoxyguanosine (analogs & derivatives, metabolism)
• Diabetic Retinopathy (drug therapy, metabolism, pathology)
• Female
• Humans
• In Vitro Techniques
• Male
• Middle Aged
• Vitreous Body (metabolism)