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The omentum is a site of stromal cell-derived factor 1alpha production and reservoir for CXC chemokine receptor 4-positive cell recruitment.

AbstractBACKGROUND:
The mechanism of the omental response to injury remains poorly defined. This study investigates the omental reaction to a foreign body, examining the role of a chemokine ligand/receptor pair known to play a crucial role in angiogenesis and wound healing.
METHODS:
A ventral hernia, surgically created in the abdominal wall of 6 swine, was repaired with silicone sheeting to activate the omentum. Omental thickness was determined by ultrasonography. Serial stromal cell-derived factor 1alpha (SDF-1alpha) concentrations were measured in blood, wound, and peritoneal fluids by enzyme-linked immunosorbent assay.
RESULTS:
During the 14-day study period, serial ultrasonography showed a 20-fold increase in omental thickness, and enzyme-linked immunosorbent assay revealed a 4-fold increase in SDF-1alpha concentration in local wound fluid. Omental vessel count and vascular surface area were 8- to 10-fold higher in reactive omentum. Immunohistochemistry showed nearly complete replacement of control omental fat with CXC chemokine receptor 4 (CXCR4)-positive cells by day 14.
CONCLUSIONS:
Activated omentum, important in the SDF-1alpha/CXCR4 axis, may serve as an intraperitoneal reservoir for recruitment of circulating bone marrow-derived cells vital to healing.
AuthorsNaveed U Saqib, Paul G McGuire, Thomas R Howdieshell
JournalAmerican journal of surgery (Am J Surg) Vol. 200 Issue 2 Pg. 276-82 (Aug 2010) ISSN: 1879-1883 [Electronic] United States
PMID20591406 (Publication Type: Journal Article)
Copyright2010 Elsevier Inc. All rights reserved.
Chemical References
  • Biocompatible Materials
  • Chemokine CXCL12
  • Receptors, CXCR4
  • Silicones
Topics
  • Animals
  • Biocompatible Materials
  • Chemokine CXCL12 (analysis, biosynthesis)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Foreign-Body Reaction (physiopathology)
  • Hernia, Ventral (physiopathology)
  • Neovascularization, Pathologic
  • Omentum (chemistry, metabolism, ultrasonography)
  • Receptors, CXCR4 (analysis)
  • Silicones
  • Swine
  • Wound Healing (physiology)

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