Abstract | AIMS: METHODS: Post hoc subgroup analysis using data of obese and non-obese participants from a large multi-centre (4555 participants with T2DM), multi-national 24-week randomized controlled trial of investigator titrated insulin glargine versus patient self-managed titrated insulin glargine. This analysis was carried out to compare two subgroups: obese (> or =30 kg/m2) and non-obese (<30 kg/m2) participants. RESULTS: The mean body mass index (BMI) values were 33.7 kg/m2(n = 1833) and 25.9 kg/m(2)(n = 2755) in obese and non-obese subjects, respectively. There was a significant reduction in glycated haemoglobin (HbA1c) from baseline in both subgroups but no significant difference between subgroups (1.15 vs. 1.15%, p = 0.50). Overall, there was a 1.21 kg (s.d. 3.3) increase in weight in individuals who were non-obese and a 1.08 kg (s.d. 3.9) increase in obese individuals (p = 0.67). There was no significant difference in the proportion of participants achieving an HbA1c of <7.0% at 6 months in both the subgroups (28.8 vs. 27.1%, p = 0.20). In multiple logistic regression, BMI was not a prognostic factor in achieving a target of HbA1c < or = 7.0%. There was no significant difference in severe hypoglycaemic episodes between obese and non-obese subgroups (1.3 vs. 1.0%); however, significantly more non-obese individuals experienced nocturnal hypoglycaemic episodes(4.5 vs. 2.4%, p < 0.05). CONCLUSIONS: In this study, treatment with insulin glargine in people with T2DM was associated with a significant reduction in HbA1c without differential increase in weight gain in obese and non-obese subgroups. Rates of severe hypoglycaemia were not different between obese and non-obese subgroups.
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Authors | K Khunti, B T Srinivasan, S Shutler, M J Davies |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 12
Issue 8
Pg. 683-8
(Aug 2010)
ISSN: 1463-1326 [Electronic] England |
PMID | 20590745
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin
- Insulin, Long-Acting
- Insulin Glargine
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Topics |
- Blood Glucose
(drug effects)
- Body Mass Index
- Body Weight
(drug effects)
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Female
- Glycated Hemoglobin
(drug effects)
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(analogs & derivatives, pharmacology)
- Insulin Glargine
- Insulin, Long-Acting
- Male
- Middle Aged
- Obesity
(drug therapy, metabolism)
- Treatment Outcome
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