Chemotherapy and interferon-alpha treatment of Erdheim-Chester disease.

Abstract

Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis of an unknown origin. The prognosis of ECD is variable, and it mainly depends on the involved anatomic sites. The treatment modalities have not been standardized. Interferon-alpha (IFN) has been reported to be effective in the management of ECD. We report here on an uncommon case with ECD in a 17-year-old female who had multiple lesions in the whole body and she was treated with chemotherapy and IFN. She has remained disease-free for 2 years after the completion of treatment.

• Authors: In-sang Jeon, Sang Seon Lee, Min Kyung Lee
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 55 Issue 4 Pg. 745-7 (Oct 2010) ISSN: 1545-5017 [Electronic] United States
• PMID: 20589628 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2010 Wiley-Liss, Inc.

Chemical References

• Interferon-alpha
• Vinblastine
• Prednisone
• Methotrexate

Topics

• Adolescent
• Erdheim-Chester Disease (diagnosis, drug therapy)
• Female
• Humans
• Interferon-alpha (therapeutic use)
• Methotrexate (administration & dosage)
• Prednisone (administration & dosage)
• Vinblastine (administration & dosage)