Chemotherapy and interferon-alpha treatment of Erdheim-Chester disease.

Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis of an unknown origin. The prognosis of ECD is variable, and it mainly depends on the involved anatomic sites. The treatment modalities have not been standardized. Interferon-alpha (IFN) has been reported to be effective in the management of ECD. We report here on an uncommon case with ECD in a 17-year-old female who had multiple lesions in the whole body and she was treated with chemotherapy and IFN. She has remained disease-free for 2 years after the completion of treatment.
AuthorsIn-sang Jeon, Sang Seon Lee, Min Kyung Lee
JournalPediatric blood & cancer (Pediatr Blood Cancer) Vol. 55 Issue 4 Pg. 745-7 (Oct 2010) ISSN: 1545-5017 [Electronic] United States
PMID20589628 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2010 Wiley-Liss, Inc.
Chemical References
  • Interferon-alpha
  • Vinblastine
  • Prednisone
  • Methotrexate
  • Adolescent
  • Erdheim-Chester Disease (diagnosis, drug therapy)
  • Female
  • Humans
  • Interferon-alpha (therapeutic use)
  • Methotrexate (administration & dosage)
  • Prednisone (administration & dosage)
  • Vinblastine (administration & dosage)

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