Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine.

Abstract

A 36-year-old female patient who was diagnosed with chronic myocarditis as an initial manifestation of systemic lupus erythematosus (SLE) was admitted to our hospital. At her third occurrence of heart failure, we performed an endomyocardial biopsy and proved chronic myocarditis with SLE. Subsequently, she was treated with prednisolone and the immunosuppressive agent mizoribine (MZR), and her cardiac function improved. We describe for the first time treatment with MZR for chronic cardiac involvement of SLE.

• Authors: Satoru Akazawa, Kunihiro Ichinose, Tomoki Origuchi, Shin-ya Kawashiri, Naoki Iwamoto, Keita Fujikawa, Toshiyuki Aramaki, Makoto Kamachi, Kazuhiko Arima, Mami Tamai, Hideki Nakamura, Hiroaki Ida, Atsushi Kawakami, Katsumi Eguchi
• Journal: Modern rheumatology (Mod Rheumatol) Vol. 20 Issue 6 Pg. 606-10 (Dec 2010) ISSN: 1439-7609 [Electronic] England
• PMID: 20582561 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucocorticoids
• Immunosuppressive Agents
• Ribonucleosides
• mizoribine
• Prednisolone

Topics

• Adult
• Female
• Glucocorticoids (therapeutic use)
• Heart Failure (drug therapy, etiology, physiopathology)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Lupus Erythematosus, Systemic (complications, drug therapy, pathology)
• Myocarditis (drug therapy, etiology, pathology)
• Prednisolone (therapeutic use)
• Ribonucleosides (therapeutic use)
• Treatment Outcome