Protein kinase D as a potential new target for cancer therapy.

Abstract

Protein kinase D is a novel family of serine/threonine kinases and diacylglycerol receptors that belongs to the calcium/calmodulin-dependent kinase superfamily. Evidence has established that specific PKD isoforms are dysregulated in several cancer types, and PKD involvement has been documented in a variety of cellular processes important to cancer development, including cell growth, apoptosis, motility, and angiogenesis. In light of this, there has been a recent surge in the development of novel chemical inhibitors of PKD. This review focuses on the potential of PKD as a chemotherapeutic target in cancer treatment and highlights important recent advances in the development of PKD inhibitors.

• Authors: Courtney R LaValle, Kara M George, Elizabeth R Sharlow, John S Lazo, Peter Wipf, Q Jane Wang
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1806 Issue 2 Pg. 183-92 (Dec 2010) ISSN: 0006-3002 [Print] Netherlands
• PMID: 20580776 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Protein Kinase Inhibitors
• protein kinase D
• Protein Kinase C

Topics

• Cell Movement
• Humans
• Neoplasm Invasiveness
• Neoplasms (drug therapy, enzymology, pathology)
• Protein Kinase C (analysis, antagonists & inhibitors)
• Protein Kinase Inhibitors (therapeutic use)
• Signal Transduction