Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study.

Abstract

Since tachykinins appear to be involved in the pathogenesis of allergic asthma, we investigated a possible association between 28 single nucleotide polymorphisms of the tachykinin genes TAC1, TAC3 and TAC4, and asthma susceptibility. A case-control study was conducted on 102 patients and 100 healthy subjects from the Canary Islands (Spain). A significant association with asthma was observed for two SNPs: rs2291855 in the TAC3 gene conferring asthma protection (Odds ratio [OR]: 0.46; 95% Confidence Interval [CI]: 0.22-0.97; P=0.038), and rs4794068 in the TAC4 gene associated with an increased risk for asthma (OR: 1.94; 95% CI: 1.06-3.54; P=0.03). The present study represents a preliminary step in elucidating the association between tachykinin gene polymorphisms and asthma susceptibility.

• Authors: Tilman E Klassert, Juan J Sánchez, Teresa A Almeida, Luz Candenas, Francisco Pinto, Orlando Acosta, Mariano Hernández
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 227 Issue 1-2 Pg. 202-7 (Oct 08 2010) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 20580442 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Neuropeptides
• TAC4 protein, human
• Tachykinins

Topics

• Asthma (genetics, immunology, metabolism)
• Case-Control Studies
• Gene Expression Regulation (immunology)
• Genetic Predisposition to Disease (genetics)
• Genetic Variation (genetics)
• Humans
• Neuropeptides (biosynthesis, genetics)
• Polymorphism, Single Nucleotide (genetics)
• Tachykinins (biosynthesis, genetics)