Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria.

Abstract

Our understanding about the role of the maternal genetic factors on placental malaria is scarce. The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy. To achieve this, 96 women with placental malaria and 180 healthy controls without malaria from the province of Luanda, Angola, were genotyped using six microsatellite loci. No associations were found between polymorphisms of genes involved in CSA synthesis and placental malaria. All these findings suggest that there is no genetic susceptibility or increased risk attributed to polymorphisms of the enzymes involved on the synthesis of CSA.

• Authors: Bianor Valente, Paulo A Campos, Virgílio E do Rosário, Henrique Silveira
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 104 Issue 10 Pg. 687-9 (Oct 2010) ISSN: 1878-3503 [Electronic] England
• PMID: 20580388 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Royal Society of Tropical Medicine and Hygiene.

Chemical References

• Sulfotransferases
• chondroitin 4-sulfotransferase

Topics

• Adolescent
• Adult
• Angola
• Female
• Genetic Predisposition to Disease
• Humans
• Malaria, Falciparum (enzymology, genetics)
• Placenta
• Placenta Diseases (genetics)
• Pregnancy
• Pregnancy Complications, Parasitic (genetics)
• Sulfotransferases (genetics)
• Young Adult