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Efficacy of intramuscular clodronate in Complex Regional Pain Syndrome type I: description of a case located in the astragalus in a patient with psoriatic arthritis.

Abstract
Reflex sympathetic dystrophy or Complex Regional Pain Syndrome type I (CRPS I) is a painful regional disease with non-metameric topography, which shows extreme pathomorphological variability, from forms in which pain is the only clinical manifestation, to "pseudo-purulent" forms characterized by impressive local manifestations. The use of high doses of bisphosphonates in the treatment of CRPS I is confirmed in different publications which associate their efficacy with their specific biological properties and multiple actions at local level. This case report describes a case of CRPS I in the astragalus of a patient with psoriatic arthritis, successfully treated with intramuscular clodronate.
AuthorsGianniantonio Cassisi, Leonardo Sartori
JournalActa bio-medica : Atenei Parmensis (Acta Biomed) Vol. 80 Issue 3 Pg. 268-77 ( 2009) ISSN: 0392-4203 [Print] Italy
PMID20578422 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Bone Density Conservation Agents
  • Clodronic Acid
Topics
  • Adult
  • Arthritis, Psoriatic (epidemiology)
  • Bone Density Conservation Agents (therapeutic use)
  • Clodronic Acid (therapeutic use)
  • Comorbidity
  • Humans
  • Injections, Intramuscular
  • Magnetic Resonance Imaging
  • Male
  • Radionuclide Imaging
  • Reflex Sympathetic Dystrophy (drug therapy, epidemiology)
  • Talus (diagnostic imaging, pathology)

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