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Contrast-enhanced sonography-guided radiofrequency ablation for the local recurrence of previously treated hepatocellular carcinoma undetected by B-mode sonography.

Abstract
BACKGROUND.: The purpose of this study was to assess the usefulness of contrast-enhanced sonography (CEUS) with Sonazoid to demonstrate local recurrence of hepatocellular carcinoma previously treated with radiofrequency ablation (RFA) and not seen on conventional sonography, prior to repeat RFA. METHODS.: This study included 16 cirrhotic patients with 17 cases of hypervascular locally recurrent hepatocellular carcinoma found by contrast-enhanced multidetector row CT (MDCT) but not seen on noncontrast sonography. We used Kupffer-phase imaging and vascular-phase imaging after re-injection. The morphologic patterns of local recurrence detected on CEUS were compared with those on MDCT. We performed repeat RFA guided by CEUS using Kupffer-phase imaging after re-injection. RESULTS.: We were able to detect on CEUS the location of all local recurrences with positive enhancement after re-injection. The morphologic patterns of local recurrence on CEUS were in concordance with those found on MDCT in all lesions. Repeat percutaneous RFA was successfully performed in all lesions. CONCLUSIONS.: The CEUS appearance of local recurrences correlated well with those on MDCT. A wider use of CEUS to guide repeat of percutaneous RFA may be possible with Sonazoid.
AuthorsNoriyuki Miyamoto, Kazuhide Hiramatsu, Kazuhiko Tsuchiya, Yukihiko Sato
JournalJournal of clinical ultrasound : JCU (J Clin Ultrasound) Vol. 38 Issue 7 Pg. 339-45 (Sep 2010) ISSN: 1097-0096 [Electronic] United States
PMID20572066 (Publication Type: Journal Article)
Chemical References
  • Contrast Media
  • Ferric Compounds
  • Oxides
  • Sonazoid
  • Iron
Topics
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular (diagnostic imaging, surgery)
  • Catheter Ablation (methods)
  • Contrast Media
  • Female
  • Ferric Compounds
  • Follow-Up Studies
  • Humans
  • Image Enhancement (methods)
  • Image Processing, Computer-Assisted (methods)
  • Iron
  • Liver (diagnostic imaging)
  • Liver Neoplasms (diagnostic imaging, surgery)
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local (diagnostic imaging, surgery)
  • Oxides
  • Treatment Outcome
  • Ultrasonography

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