Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: synthesis, characterization and in vitro antitumoral activity against chronic lymphocytic leukemia (CLL) cells.

Abstract

Four novel bidentate N,N'-ligand precursors, including O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1 x 2 HCl-L4 x 2 HCl, of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl(2) and the corresponding palladium(II) complexes 1-4, were prepared and characterized by IR, (1)H NMR and (13)C NMR spectroscopy and elemental analysis. In vitro cytotoxicity of all compounds was determined against chronic lymphocytic leukemia cells (CLL). The compounds were found to exhibit higher antitumoral activity than cisplatin. The most active compound 2, [PdCl(2){(S,S)-nPr(2)eddl}], was found to be 13.6 times more active than cisplatin on CLL cells.

• Authors: Jelena M Vujić, Milica Cvijović, Goran N Kaluderović, Marija Milovanović, Bojana B Zmejkovski, Vladislav Volarević, Nebojsa Arsenijević, Tibor J Sabo, Srećko R Trifunović
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 45 Issue 9 Pg. 3601-6 (Sep 2010) ISSN: 1768-3254 [Electronic] France
• PMID: 20570025 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antineoplastic Agents
• Esters
• Ethylenediamines
• Ligands
• Organometallic Compounds
• EDDA
• Palladium
• Edetic Acid
• Leucine

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Edetic Acid (analogs & derivatives, chemistry)
• Esters
• Ethylenediamines (chemistry)
• Humans
• Inhibitory Concentration 50
• Leucine (analogs & derivatives, chemistry)
• Leukemia, Lymphocytic, Chronic, B-Cell (pathology)
• Ligands
• Organometallic Compounds (chemical synthesis, chemistry, pharmacology)
• Palladium (chemistry)
• Spectrum Analysis